Nats hate wind
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When I started growing, one plant could get you 20 years, and 10 plants were a federal charge. In urban areas here in So Cal, people literally drove around neighborhoods at end of September, sniffing out your plants to come back and steal them overnight. So remembering those days, this is actually a tough question, but I’m going with indoor temperatures.
Many of us moved our grows indoors in the ‘80s, and there are many challenges we came upon that are far different from outdoors. Once HID lights became affordable, the big one for me was daytime heat. I was battling +100° F temps. No matter what you do, HPS bulbs are HOT compared to florescent or LED.
On average with LEDs today, your grow area will be approximately 10° F hotter than ambient. Much better than +30° average from HPS. I can keep my home between 68° and 75° max in the daytime depending on the time of year. Night time temps are always below 72°.
105° in my grow area was extremely hard on the plants.
It seems a bit obvious today, but it actually took me a more than a year before I figured out I needed to blackout the room, keep the night time house temp at 68°, and have the lights come on at 7 PM. Hey I was young and still learning a ton. Go figure. 
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One of my biggest challenges has been over feeding. I have switched over to organic nutrients and amendments which I think has been a big help. This run I have been feeding the soil more so than the plant. Great results so far. I also try to use a quality soil if I don’t make it myself.
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First biggest challenge that took me years to fully understand. Do not jar up herb thats too moist. I’ve had several batches of flower that came down smelling great and then jarred em too early/moist and resulted in straight hay terps.
Daily burping can be a budsaver but too moist into a sealed environment has always been let down for me.
Second big challenge I face out here in the low desert 
AZ is lack of water. I’ve created basin gardens and few other permaculture methods of water catchment. Very open to ideas from the community.
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A post was merged into an existing topic: Share your Setup
I had the same problem now I always use moisture packs. It can save your harvest.
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My biggest challenge to date has been learning to pace myself and do things with consistency and integrity before trying to rush and/or automate too much in my grows. Raw excitement and genuine enthusiasm will absolutely have me popping 15 seeds in one run before even thinking about how much work and/or how much space they are going to require to truly prosper and yield anything worthwhile. Providing each individual plant with the attention and care they truly deserve has become top priority for me.
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My biggest challenge in my three grows so far was maintaining a good flowering environment during 2 unseasonal heatwaves. Too hot & too humid in the spring - no thanks! Even though I grow indoors, with strong lights in flower (700-1000PPFD) & 5 girlie beanstalks exuding plenty of their own moisture, I was struggling to get the humidity below 60%. We had our home AC on constantly, with a Vivosun dehu in the tent & a room dehu outside of the tent. Lowering the lights helped, as did the dehus & some small closet humidity absorber hanging bags.
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Wow, Thank you to everyone who has shared their biggest challenge to date.
I am sure there is a couple of us that have experienced the same or even similar.
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Hey @MrNice
I can relate, if I grow outdoors here at my house, those little Spider Mites destroy my plants.
Indoors I can at least control those little critters. However my last grow was Scales. Destroyed two of my plants and to this day I still don’t know how to get rid of them.
Mosquito bites/dunks!?
One of the biggest problems I’ve had growing outdoors it’s the weather. I’ve had major drought and heavy storms that just annihilated my crops. I’m learning that support is key to keeping them from snapping! And I’m gonna use the drip irrigation system that I’m working out to keep them nice and watered!
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I’m using them and they work for fungus knats. Just have to be patient and let it break the life cycle. I think it around 21 days.
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spider mites ,been growing for 14 years ,had to clean everything
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When I was growing outdoors biggest challenge was budrot mainly because of the hot and humid climate in my region. Since growing indoors my biggest challenge is watering when on vacation or a weekend getaway.
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My nemesis!
You and me both , I feel your pain.
I’ve been nodding along like one of those dogs on the parcel shelf of the car…
Yep, Fungus Gnats, nightmare, hard to eradicate completely.
Yep curing, I built a thermo-electric curing fridge out of a wine-cooler and stripped down dehumidifier, an Inkbird to regulate humidity and another to regulate temperature. That makes it easier. This time the yield was much bigger though and I’ve had to do one shelf wet-trim to fit it in!!!
My biggest challenge is stealth and stress as I live in an area where it isn’t as straight-forward to grow. My kids can’t know, my partner only knows what she has to and I have to use cash as often as possible to keep my digital profile slim…
I could write a whole book on the question of what was difficult and problematic lol, but its the best hobby there is and the cheapest way for me to access medication…
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Unfortunately, I have not had any success so far, but then again I have only tried a couple times so far with a few seeds at a time
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Plain and simple. Trying to setup a working indoor system in the Spanish Summer. The issue is usually the total power cap on the main circuit. So either you have limitless power or you grow outdoors in the summer. Of course a basement or cellar would work.
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